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2010;4 doi: 10.1371/journal.pntd.0000900

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Taghavi et al., 2017)

T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation

However, the activity reported was very low, which could be enhanced to 963-fold for a triple mutant E423Y/E442Q/D445N of BsGGT, developed by site-directed and random mutagenesis approach (Suzuki et al., 2010)